How We Develop Enzyme Products

An understanding of how Houston Enzymes develops different products will help you in the decision of which product is right for your digestive needs.

Several points should be kept in mind concerning our products:

  1. Houston Enzymes develops unique enzyme formulations based on perceived customer needs. Feedback from our customers is vital in our product development schemes.
  2. Once a product is launched, Houston Enzymes rarely takes it off the market. This insures that once you start using our product, you don't have to worry about it being removed. The only time we remove a product is if it does not meet the standards set for the product. For this reason, you may notice that several of our products are similar. We recognize, however; that even slight changes may result in significant differences in efficacy.
  3. Our formulations are based on Dr. Houston's 25+ years of expertise in researching various enzymes and their applications. Others may claim to be "enzyme experts", but they do not have the credentials or background possessed by Dr. Houston.
  4. Houston Enzymes will always disclose the ingredients in our products. We do not hide behind "proprietary" blends that are often a means of hiding inferior formulations.

Our product line originally started with two products: Peptizyde and HN-Zyme Prime. Peptizyde was our premier DPP IV-containing (dipeptidyl peptidase "4") product for gluten, casein, soy and other food proteins. Peptizyde was targeted to address only proteins so that higher protease (enzymes that break down proteins) levels could be added per capsule. Peptizyde contains papain, a protease enzyme derived from the plant stem latex of papaya.

HN-Zyme Prime is a companion product to Peptizyde, as it is designed to help with carbohydrates, starches, sugars, and fats. Recognizing that many would want to use just one product, some proteases, notably bromelain and papain, were added. This made HN-Zyme Prime very close to a "multi-enzyme" product.

Both products were very successful. The high-protease Peptizyde worked well for those on wheat- and dairy-restricted diets, and HN-Zyme Prime helped tremendously in helping with lactose intolerance, gas, and bloating.

Then, as we accumulated customer feedback, we noted that some were noting intolerances or allergic-type reactions to the products. We concluded that the fruit-derived proteases (bromelain and papain) may be the culprits since they are derived from plant latex which can be allergenic. This led us to formulate two modified products: AFP Peptizyde and Zyme Prime. We did not discontinue Peptizyde and HN-Zyme Prime because the majority of our customer base was pleased with their use and switching to another product could upset the delicate protocols already developed and working well.

AFP-Peptizyde is very similar to Peptizyde. We took out the papain and replaced it with another enzyme purified from fungus, Protease 6.0. The DPP IV content was the same as Peptizyde, even thought the peptidase amount was lowered from 62,500 HUT to 50,000 HUT. This is probably due to the DPP IV activity present in the Protease 6.0. An additional benefit to AFP-Peptizyde was that the taste and smell was more tolerable. Papain does have a unique odor which many do not appreciate.

Zyme Prime is a modified HN-Zyme Prime formula. The bromelain and papain were removed to enhance tolerability for the latex-sensitive. One of the two fungal-derived proteases was kept in the formula to help with glycoproteins present in starches. Extra lactase and alpha-galactosidase were added since there was now more room in the capsule. We also used a cellulose filler with Zyme Prime, whereas we used rice bran in our previous formulas.

We now had 4 products that were targeted towards 2 functions, but in 2 forms to accommodate the sensitivities of our customers. Interestingly, the slight changes only increased our customer base!

Another accommodation was to produce duplicate lines of our products using cellulose and MCT oil as filler instead of rice bran, as we did with the Zyme Prime formula. This meant we were carrying the same enzyme formulas but with 2 different fillers. Again, we didn't want to choose one or the other for fear of upsetting someone's dosing regimen. We recognize that with chemically sensitive individuals, even slight changes may produce an unwanted result.

By listening to our customer's observations of the effects of these enzyme products, we can get ideas for other products. One notable observation that kept cropping up was that many children could tolerate certain fruits and vegetables better when taking Zyme Prime. We then investigated why this may be occurring and enlisted volunteers to try several different enzymes. The results of that research led to the formulation of an entirely new enzyme product called No-Fenol. This product helped those intolerant to brightly colored fruits and vegetables and helped in digesting high-fiber foods.

Houston Enzymes had resisted producing an "all-in-one" type of enzyme formula because it provided no real benefit other than buying just one product. What Peptizyde/, Zyme Prime, and No-Fenol offered was a means of focusing on a particular area of digestion: proteins, carbs, or phenolic / high-fiber foods. Because we use high amounts of each enzyme in our formulas, you would still be taking the same number of capsules of a broad-spectrum formula in order to obtain the same quantities found in the "focused" products. Recently, however, enzyme manufacturers have obtained more concentrated enzymes, meaning less mass amounts could give equivalent enzyme activities. The time was now right to produce TriEnza, our first multi-enzyme combination product.

A 2-capsule dose of TriEnza combines the equivalent of 1 capsule of AFP Peptizyde, 1 capsule of Zyme Prime, and one-half capsule of the xylanase activity of No-Fenol. In addition, no fillers were added, so the rice-bran vs. cellulose issue is gone. While the "focused" enzyme products do provide the ability to customize enzyme intake for any meal or dietary situation, TriEnza is a great product for those who need it. By waiting several years to produce the multi-enzyme product, Houston Enzymes was able to use its experience and customer feedback to produce an optimal enzyme blend that will fit a great many people.