Welcome to The Enzyme Digest where
topics on enzymes, digestion, and nutrition.
|From Devin Houston: STATUS OF ENZYME RESEARCH FOR CELIAC DISEASE
Celiac sprue, or celiac disease, is an inheritable,
gluten-induced disease of the upper small intestine
which is thought to afflict 1 in every 200 people
world-wide. The disease is characterized by
intestinal inflammation and damage to the crypts and
villi of the GI tract. This causes a decrease in
surface area for nutrient absorption resulting in
diarrhea, anemia, weight loss, and bone disorders.
The main trigger for celiac disease is gluten from
common grains such as wheat, barley, and rye.
Dietary restriction of these grains can result in
remission of the disease, however, gluten is often a
hidden ingredient in many foods.
Gluten is a complex mixture of proteins consisting of
gliadins and glutenins. The structure of these
proteins is dominated by a prevalence of proline and
glutamine residues, which makes these proteins
difficult to digest with pancreatic proteases. As a
result, long peptides from these proteins are allowed
to remain in contact with the intestinal tract wall,
initiating an antigenic response and subsequent
Prolyl endopeptidases, or PEPs can readily cleave or
degrade these proline-rich peptides, which reduces
the antigenic potential of gluten. These enzymes
yield two shorter peptides that are suitable
substrates for further cleavage by intestinal
Recently, great strides have been made in identifying
peptidases that may eventually be used as oral
treatments for celiac disease. Of interest to the
public is the finding that multiple-protease therapy is
better than the use of a single protease enzyme.
HNI has maintained that vary notion for many years.
The enzymes of interest in celiac research are from
two research labs. Dr. Chaitan Khosla at Stanford
University is experimenting with a two-enzyme
mixture consisting of: 1) an enzyme derived from
barley, known as EP-B2, and 2) FM-PEP, a dipeptidyl
peptidase isolated from the bacteria Flavobacterium
meningosepticum. In the Netherlands, Dr. Frits
Koning at Leiden University is using a PEP derived
from Aspergillus niger, a fungal organism used
extensively in commercial production of food-grade
Dr. Khosla's research uses enzymes from recombinant
sources; i.e. the gene for the enzymes is actually
produced in E. coli, in order to increase production.
Many are averse to using materials from genetically-
modified organisms (GMOs), however, it may be the
only method to produce these enzymes in sufficient
Dr. Koning's group uses an enzyme from Aspergillus
niger that is part of the same family as the DPP IV
found in many enzyme products (found to be in
commercially available enzyme blends by Dr.
Houston). They have designated this enzyme as AN-
PEP, and can be produced as a food-grade enzyme.
This enzyme may be superior to the FM-PEP, as it is
acid-stable, and needs no special enteric coating for
it to survive in the stomach. In fact, AN-PEP is
actually more active in acidic conditions (as are most
fungal enzymes) and so is ideal as an oral supplement
for potential celiac therapy.
However, both research groups plan clinical trials for
using these enzymes as a therapy for celiac disease.
In order to make such health claims, if the trials are
successful, the "new" enzymes will be designated
as "drugs" and must go through an expensive,
lengthy approval process for FDA approval as a
treatment. The approval process may take as long
as seven years before being made available as a
prescription or over-the-counter product.
Those suffering from celiac disease who wish to
experiment with available peptidase enzyme products
should be aware that NO enzyme company should be
making claims as to effectiveness for celiac disease.
Enzyme supplementation may be helpful to celiac
sufferers for general digestive help but they are
encouraged to remain gluten-free.
|Updated HNI Website
Take a look at the updated HNI website at
more organized and easier to find and the online
ordering system is improved. No account is
to order and discounts now show up on invoices.
calendar alerts users of
Events. In the
Newsletter Archives, readers can
find past issues of the newsletter.
Watch for more website changes coming soon,
the addition of Paypal as a form of payment, a page
Dr. Houston's research background, and a section for
new enzyme research articles.
|HNI Video Wins Award
Siloam Springs, Ark. - Two downtown Siloam Springs
businesses collaborated to win a
national award honoring excellence in media
production. Houston Nutraceuticals, Inc.
and Gray Communications, Inc. created a DVD
promoting the benefits of HNI's line of
products and showing three unique perspectives to
help educate potential customers.
The DVD, which promotes the digestive benefits of
using enzymes, features a section of
customer testimonials, a seminar taught by the
President and CEO of HNI, Devin
Houston, Ph.D., and a laboratory segment with
experiments shot in a kitchen similar to
a TV cooking program.
"Our business relies heavily on conveying technical
information about our products,
usually through personal contact with parent support
groups," explained Houston. The
challenge for HNI is the time and resources required
to visit all of these groups. "Using the video
produced by Gray Communications, we can reach
more groups at a fraction of the cost. Our
customers are very impressed by the professionalism
of the production."
Debbie Montes, an HNI customer from California
said, "This is the first time in a long time
that I am hopeful again. The demonstrations with
the enzymes were impressive and
the thorough explanations made by Dr. Houston
convinced me to start my son on
enzymes immediately. Thank you for making it easy
for me to understand."
The Telly Awards is a widely known and highly
respected international competition,
which annually receives over 12,000 entries
worldwide. The award was given in the Health,
Medicine and Wellness category.
Pictured above is Dr. Devin Houston with Todd
Robertson, Project Manager for Gray.
To request a DVD at no cost, please
firstname.lastname@example.org or call
|Boy Drinks Milk! No Problems!!
I have to write you and thank you for your
developing such a fine product!
switched places at the
dinner table last night. My younger son drinks 2%
the older son with ASD (autism spectrum disorder)
drinks rice milk. The older boy drank the
2% milk before
we could realize it. I gave him an extra
Peptizyde and we
began to pray! Usually he would have been
throwing up in the
night followed by a severe sneeze attack. He
slept through the
night without a problem and woke up feeling
fine. Thank you so
|Dr. Houston Speaking at ASA, USAAA, and Regional Groups
Pictured at right is Dr. Houston with Mandi Rodwell
at the Autism One conference where Dr. Houston
was a speaker.
son was one of HNI's early customer success stories
and Mandi has recently become an HNI Distributor in the
Providence, Rhode Island; July 13-15.
US Autism & Asperger's Association
Conference, Park City, Utah; August 9-12.
HEAR (Helping Educate about Autism Recovery)
parent support group, Little Rock, Arkansas;
September 18. Contact Susan at
Society of the Panhandle, Pensacola, Florida;
October 17. Email Lisa Branton at
FEAT Fort Smith, Arkansas; November 16. Email
Mandy Steele at
Dr. Houston holds an earned PhD in Biochemistry and
has extensive research background in enzymes. He
cost to parent groups and parent conferences.
Check for Calendar
To request a presentation, contact Cindy
Kelley toll free at 1-866-275-0915 or