• SALE on No-Fenol Chewable version! Get 25% off retail price on Chewable version only, use code CHEWMORE at checkout.*
  • Better breakdown of fruits and vegetables
  • Helps with digestion of phenols (polyphenols)
  • Tends to soften stools
  • Capsules or chewable tablets
  • Capsule version label has a new look - same great formula!
  • Description
  • Ingredients
  • Dosage
  • FAQs
  • Video

*SALE on No-Fenol Chewable version. Get 25% OFF retail price of chewable version only (does not apply to capsule version). Not to be combined with any other discounts. No limit on number of bottles. Use code CHEWMORE at checkout.

No-Fenol was developed by Dr. Devin Houston in response to parents' request for a product that would allow their children to eat fruits and vegetables without the problems thought to be associated with polyphenolic compounds. Initial response from many parents indicate that for many, No-Fenol does allow the addition of these foods to the diet without complications.

All plants contain some degree of phenolic compounds. The phenol structure itself is ubiquitous in nature, and is actually essential to many of life's processes. Current thinking by many is that some subset of children on the PDD spectrum have difficulty in the processing of phenolic compounds, which may present as behavioral problems and physical symptoms such as red ears and cheeks, and dark circles under the eyes. While the basic mechanism behind this phenomenon is not well defined, it is thought that perhaps the phenolic compounds become "trapped" in some part of a metabolic cycle, presumbably involved with various detoxification pathways.

The research literature indicates that some phenolic compounds are modified by the addition of carbohydrate groups to their structures, which may inhibit their crossing into cells and being metabolized. The current hypothesis for why No-Fenol may help is through the ability of the enzymes in this product to remove the carbohydrate groups from the phenols, thus allowing normal processing by the detoxification pathways. There is no evidence that No-Fenol directly modifies phenolic structures. Indeed, the success of No-Fenol in allowing the addition of phenolic foods back into the diet of children with PDD may result in a re-evaluation of the basis of the phenol "problem".

Xylanase is the major component of No-Fenol, and is an enzyme used to breakdown the structural components of plant cell walls, which are primarily very complex carbohydrates. Xylanase is used in the juice industry to extract more juice from fruit pulp fibers. At least one reference indicates that polyphenolic compounds are actually increased by treatment with xylanase. Based on this reference and the fact that No-Fenol has allowed "phenol-sensitive" individuals to ingest phenolic foods, Houston Enzymes now believes that the phenol issue is much more complex than previously thought, and may not be due so much to the presence of phenols as to the specific structure of these phenols.


No-Fenol capsules contains cellulose/medium-chain triglyceride oil (MCT oil) as filler. MCT oil is derived from palm oil, and the cellulose is derived from European Spruce trees. The capsule is also cellulose.


Contraindications for Enzyme Supplementation

This product may not be appropriate for those with known allergies to enzyme proteins, though non-specific mold allergies do not necessarily preclude use of fungal enzymes. Consult your medical doctor for further advice, and err on the side of caution. Those with known anaphylactic allergic reactions to fungal proteins should NOT ingest fungal-derived enzymes.

No-Fenol Capsules

Supplement Facts

Serving Size: 1 Capsule

Servings per Container: 90

Amount Per Serving % Daily Value
Enzyme Blend 288 mg *
Xylanase 32,000 XU
CereCalasetm (1,500 MU) Hemicellulase, beta-glucanase, phytase 75 mg *
*Daily Value Not Established

OTHER INGREDIENTS: Vegetable capsule (cellulose and water), cellulose and Medium Chain Triglycerides. No added sugar, starch, dairy, soy, wheat, yeast, gluten, nuts, artificial flavors, or animal derivatives. 
CereCalase® is a registred trademark of National Enzyme Company. 

For a free sample, contact us by emailing, or calling US toll-free 866-757-8627 or International 479-549-4536. 

No-Fenol Chewables

Supplement Facts

Serving Size: 2 Tablet

Servings per Container: 90

Amount Per Serving % Daily Value
Enzyme Blend Weight 317 mg *
Xylanase 32,000 XU *
CereCalasetm (1500 MU) Hemicellulase, beta-glucanase, phytase 83 mg *
*Daily Value Not Established

Other Ingredients: Fructose, natural pomegranate flavor, hydroxypropyl cellulose, natural raspberry flavor, magnesium stearate, citric acid, silica, monoammonium glycyrrhizinat (flavor enhancer from licorice), sodium chloride. No added starch, dairy, yeast, wheat, gluten, corn, soy, nuts, preservatives, artificial colors, artificial flavors or animal derivatives.

For a free sample, contact us by emailing, or calling US toll-free 866-757-8627 or International 479-549-4536. 


No upper limit has been established for oral enzyme supplementation. Animal studies indicate that extremely large doses of enzymes may be ingested without toxicity or ill effect. No upper limit has been established for enzyme dosing, and animal studies found no toxicity at dosing as high as 80,000 FXU per kilogram of body weight per day for 13 weeks. No-Fenol is recommended primarily for those with known sensitivities to phenolic compounds.

½ to 1 capsule (or 1 to 2 chewable tablets) usually suffices for most meals, but not necessarily with every meal. Some have found satisfactory results with once or twice per day dosing, indicating that optimal dosing may be dependent upon many factors. High doses can decrease firmness of stools. Decrease dose if stools become too soft - or add Zyme Prime.

Feel free to vary the dosage of No-Fenol based on content and size of meal. Those meals higher in phenols may call for higher doses of No-Fenol. For reasons of practicality, no more than 3 capsules need be taken at one time.

No-Fenol Chewables

As a dietary supplement, chew 1 - 2 tablets with meals or snacks. Dosing is not by age or body weight, but by how much food is eaten. Note that it now takes 2 chewable tablets to equal the potency of 1 No-Fenol capsule.

Store in a cool, dry place away from direct light and humid conditions. Do not refrigerate, keep at room temperature. Cold does not harm the enzymes, but most refrigerators are high-humidity environments. Freezing is acceptable and encouraged for long-term storage.

Can I take No-Fenol with my medications?

  • No-Fenol can be taken with most medications. However, caution should be exercised when using sustained-release medications that use cellulose as part of the time-release mechanism, as it may affect dosing. It should be noted that no study has yet been carried out to detemine whether this action actually occurs.

Will taking oral enzymes cause my pancreas to stop making enzymes?

  • No. Studies have shown little or no effect of oral enzymes on pancreatic enzyme production. The pancreas enzyme production is not regulated by a feedback system, and has no way of determining whether you are taking oral enzymes.

What is the dosing for No-Fenol?

  • No one dose is suitable for all. Dosing is not calculated based on age or body weight, but by how much is eaten in any one meal. Large meals or meals with foods that may not be well-tolerated, may require higher levels of enzyme. No toxicity occurs at any dosing level for enzymes so you can take many with no worry of side effects. We encourage some experimentation to find the amount that works best for you.  ½ to 1 capsule per meal (or 1 to 2 chewables) seems to be fine for most, however. You may try more as needed.

Here is our extensive FAQ section.

90 capsules (90 doses)

$29.00 Learn MoreLearn More

No-Fenol Chewables
180 tablets (90 doses)

$32.00 Learn MoreLearn More