AFP Peptizyde

  • Enzyme combination for digestion of food protein
  • Supports breakdown of dairy and wheat proteins
  • Includes Dipeptidyl Peptidase IV (DPP IV) enzyme activity
  • Safe, non-toxic supplement for the GFCF Diet†
$41.99 Select a Size Choose from options below

AFP Peptizyde

90 capsules (90 doses)

AFP Peptizyde

HN004-S90 90 capsules (90 doses) $41.99

AFP Peptizyde

HN004-S90 | 90 capsules (90 doses)

Contains cellulose and MCT oil for dust control, approximately 1 mg per capsule. 

  • Enzyme combination for digestion of food protein
  • Supports breakdown of dairy and wheat proteins
  • Includes Dipeptidyl Peptidase IV (DPP IV) enzyme activity
  • Safe, non-toxic supplement for the GFCF Diet†
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AFP Peptizyde

AFP Peptizyde® (Advanced Formula Protease) is a combination of three different enzymes that break down food proteins. These enzymes are isolated and purified from fungal sources.

The combination of these specific enzymes allows much more efficient means of quickly and thoroughly breaking proteins into smaller components.

The enzymes in AFP Peptizyde work only on food proteins — not carbohydrates, fats, nor other compounds. AFP Peptizyde won't interfere with medications or other supplements unless they are also proteins, which is extremely unlikely. AFP Peptizyde may be used in combination with other enzyme products. 

More About How AFP Peptizyde Works

The enzyme dipeptidyl peptidase IV, or DPP IV, is able to break down and inactivate the exorphin peptide casomorphin, from dairy. However, for maximal protein breakdown, DPP IV is not useful alone, and should be combined with other proteases with different and less stringent peptide bond specificity.

For this reason, AFP Peptizyde contains two other fungal-derived proteases with high activity in acid conditions. These enzymes are present in AFP Peptizyde in high amounts for the purpose of quickly hydrolyzing (breaking down) proteins while the food is still in the stomach.

The ability of AFP Peptizyde enzymes to withstand the low pH of the stomach and remain active under acidic conditions allows breakdown of casein and gluten prior to entrance into the small intestine. Casein and gluten, in the presence of pancreatic enzymes in the small intestine, can produce exorphin peptides that may be readily absorbed from the intestine (these peptides are not absorbed from the stomach).

AFP Peptizyde supplements the "normal" breakdown of casein, gluten, and other food proteins such that the exorphin peptides are less likely to be produced. The additional acid-stable protease activity provided by AFP Peptizyde allows protein break down to occur earlier and more thoroughly since very little protease activity exists in the stomach.

AFP Peptizyde also contains only those enzymes needed for protein hydrolysis. No other enzymes, such as those for carb and fat digestion, have been added. This allows you to customize enzyme supplementation to your specific dietary needs.

Another advantage to this approach is that less potential exists for intolerance reactions due to additional and perhaps unnecessary enzyme proteins. Also, by using only three enzyme blends in AFP Peptizyde, larger amounts of each enzyme can be added per capsule. This ensures that more breakdown of the food protein can take place in the short time that food is in the stomach.

AFP Peptizyde is NOT intended to allow gluten back in the diet for those with celiac disease. Anyone with celiac disease should maintain a gluten-free diet. No supplement will allow those with celiac disease to ingest gluten.


AFP Peptizyde is recommended for high protein diets, and dosing may be increased for those meals. We recommend no more than 3 capsules be taken at any one time.†

Contraindications for Enzyme Supplementation

These enzymes should be used with care in cases of active stomach or duodenal ulcers, severe bowel inflammation (characterized by blood in stools), hemophilia and other bleeding disorders, or within a week of scheduled surgery. This product may not be appropriate for those with known allergies to Aspergillus enzyme proteins, though non-specific mold allergies do not necessarily preclude use of fungal enzymes. Consult your medical doctor for further advice, and err on the side of caution. Those with known anaphylactic allergic reactions to fungal proteins should NOT ingest fungal-derived enzymes.

Peptizyde® is a trademark of Houston Nutraceuticals, Inc.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 


AFP Peptizyde capsules

Supplement Facts

Serving Size: 1 Capsule         Servings: 90


 Amount Per Serving% Daily Value
Protease 31,875 HUT *
Protease 6.0 25,500 HUT *
Neutral Bacterial Protease 51,000 PC *
Peptidase 12,750 HUT *
      DPP IV 255 DPPU *
*Daily Value Not Established

Other Ingredients: Capsule (hypromellose and water), microcrystalline cellulose powder, and medium chain triglyceride oil powder.

This product includes the following materials that are either derived from or contain allergens which must be declared on labels per the US Food Allergen Labeling and Consumer Protection Act (FALCPA): 

The production process used to manufacture the enzymes found in this product utilizes fermentation materials that are derived from or contain the allergens listed below. While these fermentation materials should be either consumed during fermentation or removed from the enzyme during additional enzyme isolation steps, minute traces of these allergens may be left in the final enzyme product. While these traces are expected to be below the limits of detection for standard ELISA based allergen testing methods‡, we cannot guarantee the complete absence of these allergens:
Wheat (gluten), soy. 

‡NOTE: Enzymes and probiotics can interfere with common ELISA based allergen test kits, producing either false positives or false negatives in these tests. When performing allergen testing on enzyme containing products, special sample preparation techniques must be utilized to avoid this interference. 



AFP Peptizyde Capsules 

No upper limit has been established for enzyme dosing. Most find using 1 to 3 AFP Peptizyde capsules per meal adequate, and most likely no further benefits will occur with higher dosing. We encourage some experimentation to find the dose that best helps each person.†

Frequently Asked Questions

If the capsule is opened and contents put on food or in drink, will the proteases hurt the mouth or throat?

The proteases should not be harmful if taken without the capsule. Some irritation may occur if the enzyme remains on the cheeks or gums due to a debriding action on the layer of dead skin cells. We recommend drinking or eating after taking the enzymes to clear the mouth of the enzymes, or brushing teeth, gargling, etc.†

Will AFP Peptizyde help those with celiac disease?

We make no claims for enzymes helping any disease condition. Celiac disease is very serious and those with the disease should stay on the doctor-advised gluten-free diet. Taking the enzymes while maintaining a gluten-free diet should do no harm.

Do I need to be on the GFCF diet for AFP Peptizyde to work?

No, AFP Peptizyde will work regardless whether one is on the GFCF diet. Many use it as an alternative to the GFCF diet with very good results.†