Will taking oral enzymes long-term stop the pancreas from functioning?

Answer: No. Pancreatic enzyme secretion is due to hormonal signals resulting from mechanical stretching of the stomach wall as food enters as well as from the act of chewing, tasting and smelling food. Research has shown some adaptability of the pancreas in animals; giving oral enzymes resulted in a slight decrease in pancreatic enzyme output that quickly returned to normal once enzymes were stopped.


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